W. Todd Cade, PT, PhD

Dr. W. Todd Cade

Professor

Division Chief

Phone: 919-660-9825

Office: 311 Trent Drive, Office #2220

Email: todd.cade@duke.edu

 

 

  • Postdoctoral fellowship, Endocrinology & Metabolism, Washington University School of Medicine, 2002 – 2005
  • Ph.D., Rehabilitation Science, University of Maryland, Baltimore, 2002
  • MS, Physical Therapy, University of Miami, 1994
  • BS, Kinesiological Sciences, University of Maryland, College Park, 1991
     

Teaching

  • PT 638: Exercise Prescription in the Continuum of Care
  • PT 639: Foundational Cardiovascular and Pulmonary Practice

Practice

Cardiovascular physical therapy, neuromuscular disease, home health, Veterans care

Research

Our laboratory aims to study mechanisms of and treatments (exercise/nutritional/exercise/pharmacologic/gene therapy) for substrate (e.g. amino acid, glucose, fatty acid) metabolism and metabolic, energetic, and functional abnormalities in skeletal muscle, heart, adipose tissue, liver and brain. We study metabolic diseases including: Barth syndrome and other pediatric and adult cardiomyopathies, HIV-related metabolic syndrome, diabetes mellitus, and obesity. We are also interested in the effect of the maternal metabolic environment during pregnancy on in utero development and childhood metabolic disease including obesity, diabetes, and HIV. We are in particularly interested in the use of exercise as a tool to study and intervention to improve metabolism and function in the cardio-metabolic health of these conditions. Our lab employs methodology used to measure whole-body substrate metabolism by stable isotope tracers and mass spectrometry, myocardial substrate metabolism by radio-isotopes and PET imaging, heart and skeletal muscle energetics by magnetic resonance spectroscopy (MRS), peak fitness assessment by graded exercise testing and indirect calorimetry, cardiac function by echocardiography, vascular function by peripheral arterial tonometry and applanation tonometry, body composition analysis by dual-energy x-ray absorptiometry (DXA) and air displacement plethymosgraphy, muscle strength by isokinetic dynamometry, and daily physical activity by actigraphy.

Recent publications

  1. Cao C, Yang L, Cade WT, Racette SB, Park Y, Cao Y, Friedenreich C, Hamer M, Stamatakis E, Smith L. Association Between Cardiorespiratory Fitness and Premature Death Among Young and Middle-Aged Americans in Recent Generations. Am J Med. 2020 Jan 29. pii: S0002-9343(20)30054-1. doi: 10.1016/j.amjmed.2019.12.041. [Epub ahead of print]
  2. Roberts JD, Liu Q, Smith L, Cao C, Jackson SE, Zong X, Meyer GA, Yang L, Cade WT, Zheng X, Wu X. Association of hot tea consumption with body fat in the US population. Obesity (Silver Spring). 2020 Feb;28(2):445-451.
  3. Tinius RA, Blankenship M, Furgal K, Cade WT, Pearson K, Rowland N, Maples JM. Metabolic flexibility during late pregnancy is impaired in obese women and associated with insulin resistance and inflammation. Metabolism. 2020 Jan 10;104:154142.
  4. Bittel AJ, Bittel DC, Mittendorfer B, Patterson BW, Okunade AL, Yoshino J, Porter LC, Abumrad NA, Reeds DN, Cade WT. A single bout of resistance exercise improves postprandial lipid metabolism in overweight/obese men with prediabetes. Diabetologia. 2019 Dec 23. doi: 10.1007/s00125-019-05070-x. [Epub ahead of print].
  5. Cade WT, Bohnert KL, Reeds DN Bittel AJ, de las Fuentes L, Bashir A, Pacak CA, Byrne BJ, Gropler RJ, Peterson LR. Myocardial glucose and fatty acid metabolism is altered and associated with lower cardiac function in young adults with Barth syndrome. J Nucl Cardiol, 2019 Nov 8. doi: 10.1007/s12350-019-01933-3. [Epub ahead of print].
  6. McGill JB, Johnson M, Hurst S, Cade WT, Yarasheski KE, Ostlund R, Schechtman KB, Razani B, Kastan MB, McClain DA, de las Fuentes L, Davila-Roman VG, Ory DS, Wickline SA, Semenkovich CF. Low dose chloroquine decreases insulin resistance in human metabolic syndrome, does not reduce carotid intima media thickness: a randomized, placebo-controlled clinical trial. Diabetol Metab Syndr (2019) 11:61
  7. Tinius RA, Blankenship M, Maples J, Cooley B, Furgal K, Norris, Furgal K, Norris E, Hoover D, Olenick A, Cade WT. Validity of the 6-minute walk test and YMCA submaximal cycle test in physically active women during mid-pregnancy. J Strength Cond Res 2019, Volume Publish Ahead of Print doi: 10.1519/JSC.0000000000003263.
  8. Baumann A, Hooley C, Mutabazi V, Brown A, Reeds DN, Cade WT, de las Fuentes L, Proctor E, Karengera S, Schechtman K, Goss C, Launois P, Mutimura E, Davila-Roman VG. Dissemination and Implementation Program in Hypertension in Rwanda: Report on Initial Training and Evaluation Global Heart. 2019 June 14: 135-141.
  9. Suzuki-Hatano S , Sriramvenugopal M, Ramanathan M, Soustek S, Byrne BJ, Cade WT, Kang P, Pacak C. Increased mtDNA Abundance and Improved Function in Human Barth Syndrome Patient Fibroblasts Following AAV-TAZ Gene Delivery. Int J Mol Sci. 2019 Jul 11;20(14):3416. doi: 10.3390/ijms20143416.
  10. Lang CE, Cade WT. A step towards the future of seamless measurement with wearable sensors in pediatric populations with neuromuscular disease. Muscle Nerve 2019 2020 Mar;61(3):293-300.
  11. Tinius RA, López JD, Cade WT, Stein RI, Haire-Joshu D, Cahill AG. Patient and obstetric provider discordance regarding weight gain recommendations among overweight and obese socioeconomically disadvantaged African American women. Women Health. 2019 May 16:1-12.
  12. Cade WT, Bohnert KL, Peterson LR, Patterson BW, Bittel AJ, Okunade AL, de Las Fuentes L, Steger-May K, Bashir A, Schweitzer GG, Chacko SK, Wanders RJ, Pacak CA, Byrne BJ, Reeds DN. Blunted Fat Oxidation upon Submaximal Exercise is Partially Compensated by Enhanced Glucose Metabolism in Children, Adolescents and Young Adults with Barth Syndrome. J Inherit Metab Dis. 2019 May;42(3):480-493.
  13. Haire-Joshu D, Cahill AG, Stein RI, Cade WT, Woolfolk CL, Moley K, Mathur A, Schwarz CD, Schechtman KB, Klein S. Randomized Controlled Trial of Home‐Based Lifestyle Therapy on Postpartum Weight in Underserved Women with Overweight or Obesity. Obesity. 2019 Apr;27(4):535-541.
  14. Suzuki-Hatano S Saha M, Soustek M, Kang P, Byrne BJ, Cade WT, Pacak C. AAV9-TAZ Gene Replacement Ameliorates Cardiac TMT Proteomic Profiles in a Mouse Model of Barth Syndrome. Mol Ther Methods Clin Dev. 2019;13:167-179.
  15. Cade WT. The manifold role of the mitochondria in skeletal muscle insulin resistance. Curr Opin Clin Nutr Metab Care. 2018 Jul; 21(4): 267-272. PMID: 29847447
  16. Engelstad HJ, Barron L, Moen J, Wylie TN, Wylie K, Rubin DC, Davidson N, Cade WT, Warner BB, Warner BW. Remnant Small Bowel Length in Pediatric Short Bowel Syndrome and the Correlation with Intestinal Dysbiosis and Linear Growth. J Am Coll Surg. 2018 Oct;227(4):439-449.
  17. Suzuki-Hatano S, Saha M, Rizzo SA, Witko RL, Gosiker BJ, Ramanathan M, Soustek MS, Jones MD, Kang PB, Byrne BJ, Cade WT, Pacak CA. AAV-Mediated TAZ Gene Replacement Restores Mitochondrial and Cardioskeletal Function in Barth Syndrome. Hum Gene Ther. 2018. 019 Feb;30(2):139-154.
  18. Cade WT, Bohnert KL, Reeds DN, Peterson LR, Bittel AJ, Bashir A, Byrne BJ, Taylor CL. Peak oxygen uptake (VO2peak) across childhood, adolescence, and young adulthood in Barth syndrome: data from cross-sectional and longitudinal studies. PLoS One. 2018 May 24: 13(5): e0197776.
  19. Morgan KA, Taylor KL, Tucker SM, Cade WT, Klaesner JW. Exercise testing protocol using a roller system for manual wheelchair users with spinal cord injury. J Spinal Cord Med. 2018 Mar 8:1-15.
  20. Abraham M, Colllins CA, Flewelling S, Camazine M, Cade WT, Cahill AG, Duncan JG. Mitochondrial inefficiency in infants born to overweight African-American mothers. Int J Obes (Lond). 2018 Jul;42(7):1306-1316.
  21. Bittel AJ, Bohnert KL, Reeds DN, Peterson LR, Corti M, Taylor C, Byrne BJ, Cade WT. Reduced muscle strength in Barth Syndrome may be improved by resistance exercise training: a pilot study. JIMID Rep. 2018;41:63-72.
  22. Cahill AG, Haire-Joshu D, Cade WT, Stein RI, Woolfolk CL, Moley K, Mathur A, Schechtman K, Klein S. Weight control program and gestational weight gain in disadvantaged women with overweight or obesity: a randomized clinical trial. Obesity (Silver Spring). 2018 Mar;26(3):485-491.
  23. Rohatgi KW, Tinius RA, Cade WT, Martinez E, Cahill AG, Parra DC. Relationships between consumption of ultra-processed foods, gestational weight gain and neonatal outcomes in a sample of US pregnant women. Peer J, 2017 Dec 7;5:e4091.
  24. Cade WT, Levy PT, Holland MR, Sing GT, Reeds DN, Cahill AG.  Markers of maternal and infant metabolism are associated with ventricular dysfunction in infants of obese women with type 2 diabetes. Pediatr Res 2017 Nov; 82(5): 768-775.
  25. Reeds DN, Pietka TA, Yarasheski KE, Cade WT, Patterson BW, Okunade A, Abumrad NA, Klein S. HIV infection does not prevent the metabolic benefits of diet-induced weight loss in women with obesity. Obesity (Silver Spring). 2017 Apr; 25(4): 682-688.
  26. Bashir A, Bohnert KL, Reeds DN, Peterson LR, Bittel AJ, de las Fuentes L, Pacak CA, Byrne BJ Cade WT. Impaired cardiac and skeletal muscle bioenergetics in children, adolescents and young adults with Barth syndrome. Physiol Rep. 2017, Feb; 5(3).

Link to complete list of publications

Grants and Awards

Current

  • 2018-2023
    “Mechanisms and Treatment of Cardioskeletal Dysfunction in Barth Syndrome”

    NIH R01 HL136759  (PI: Pacak C, University of Florida, Role: Subcontract PI)
     
  • 2017-2020
    “Characterization of the ‘Metabolic Phenotype’ in Barth Syndrome with Cardiac Transplantation”
    Barth Syndrome Foundation (PI: Cade WT)                                                                     

Previous (Selected)

  • 2018-2020
    “Acute Effects of Aerobic and Resistance Exercise on Maternal Glucose Metabolism and Vascular Function in Obese Pregnancy”
    National Rehabilitation Research Resource to Enhance Clinical Trials (REACT) (PI: Cade WT)
  • 2015-2020
    “Exercise Training to Improve Brain Health in HIV+ Individuals”

    NIH 1 R01 NR015738-01A1 (PI: Ances B, Role: Co-I)                                           
     
  • 2015-2020
    “Effects of Resistance Exercise Training on Cardiac, Metabolic and Muscle Function and Quality of Life in Barth Syndrome: Part 2”
    Barth Syndrome Foundation (PI: Cade WT)                                
  • 2016-2020
    “HIV- and ART-Associated Cardiometabolic Research Training in Rwanda”

    D43 TW010335 01 (PI: Mutimura E, Role: Co-I)                                                  
     
  • 2017-2022
    “Combining Testosterone Therapy and Exercise to Improve Function Post Hip Fracture”
    NIH R01 AG051647-01  (PI: Binder E, Role: Co-I)                                 
  • 2018-2020
    “Effectiveness of Resistance Exercise Training Program in Youth with CF”

    Cystic Fibrosis Foundation  (PI: Granados A, Role: Co-I)                                      
     
  • 2018-2021
    “The Inorganic Nitrate for Exercise in Heart Failure (INIX-HF) Trial”

    NIH R34 HL138253 02 (PI: Peterson LR, Role: Co-I)
     
  • 2012-2018
    “Weight Management in Obese Pregnant Underserved African American Women”
    NIH U01 DK094416 (NCE) (PI: Klein S, Haire-Joshu D, Cahill AG, Role: Co-I)            

     
  • 2012-2019
    “Heart and Skeletal Muscle Nutrient Metabolism, Energetics and Function in Barth Syndrome”
    NIH 1 R01HL107406-01A1 (PI: Cade WT)

                                                                    
  • 2010-2013
    “Safety and Efficacy of Aerobic Exercise Training in Barth Syndrome”
    Barth Syndrome Foundation (PI: Cade WT)                                                                         

     
  • 2011-2014
    “Maternal Lipid Metabolism and Neonatal Heart Function in Diabetes Mellitus”

    Thrasher Research Fund (PI: Cade WT)                                                              
     
  • 2010-2012
    “Left Ventricular Function in HIV-Negative Children Exposed to HIV and HAART in Utero”
    GlaxoSmithKline HIV Collaborative Investigator Research Award (PI: Cade WT)       

     
  • 2009-2012
    “Characterization of Nutrient Metabolism in Barth Syndrome”

    Barth Syndrome Foundation (PI: Cade WT)
                                                                                          
  • 2006-2011
    “Exercise and TZD Effects on Myocardial Substrate Metabolism and Function in HIV”
    Mentored Research Scientist Development Award NIH KDK074343A (PI: Cade WT)
                                                                          
  • 2004-2005
    “Lipid Kinetics During Acute Exercise in HIV”

    NIH F32 DK066977-01 National Research Service Award, Postdoctoral Fellowship(PI: Cade WT)
     
  • ACSM Mid-Atlantic Chapter President’s Award 2001
     
  • VA Health Scholarship Award 1993-94