DOCTOR OF PHYSICAL THERAPY DIVISION

Academic Appointments

Assistant Professor

 

 

Education

Massachusetts General Hospital Institute of Health Professions, DPT, 2005

University of North Carolina at Chapel Hill , MS in Physical Therapy, 1992

University of North Carolina at Chapel Hill , Postgrad Fellowship in Pediatric PT, 1984

Ithaca College , BS in Physical Therapy, 1978

 

Teaching Responsibilities

Primary Course Instructor for the following:

PT304 - Human Development – fall

PT504 - Pediatric Practice Elective – fall

PT327 - Patient/Client Management Seminar I – summer

Co-Instructor for the following:

PT404 - Neurological Practice Management I – fall

PT412 - Neurological Practice Management II – spring

Invited Speaker

PT325 - Medical Practice Management - Juvenile Rheumatoid Arthritis

PT504 - P&O Elective - Pediatric Orthotic Intervention – fall

Faculty participant

PT306 Professional Development Seminar - fall

PT511 Portfolio

PT508 Evidence-based Practice III / EBP Capstone Project 

Practice

Pediatric Physical Therapy with particular emphasis on children with neuromusculoskeletal diagnoses including CNS dysfunction (cerebral palsy, traumatic brain injury), motor unit diseases and disorders (muscular dystrophy, spinal muscular atrophy, Pompe disease, and other Glycogen storage diseases), myelodysplasia, other neuromuscular disorders and developmental delay, and systemic disorders, such as juvenile rheumatoid arthritis. Clinical responsibilities including direct physical therapy treatment, casting and orthotic intervention, assistive technology, and coordination with the rest of the medical team regarding patient candidacy for such interventions as serial casting, Botox injections, Baclofen pumps, selective dorsal rhizotomy. Practice includes emphasis on the continuum of care across the lifespan of individuals with diagnoses with onset during childhood. 

Research

Developmental neuroscience, including issues such as plasticity, recovery, and adaptability of the nervous system; developmental biomechanics, dynamic systems and dynamic functioning of the neuromusculoskeletal system, motor control and motor learning, exercise and clinical management of neuromuscular disease and disorders. 

Selected Publications

• Katharine Bushby, Richard Finkel, David J Birnkrant, Laura E Case, Paula Clemens, Linda Cripe, Ajay Kaul, Kathi Kinnett, Craig McDonald, Shree Pandya, James Poysky, Frederic Shapiro, Jean Tomezsko, Carolyn Constantin, for the DMD Care Considerations Working Group. Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care. Lancet Neurology (in press).
• Katharine Bushby, Richard Finkel, David J Birnkrant, Laura E Case, Paula Clemens, Linda Cripe, Ajay Kaul, Kathi Kinnett, Craig McDonald, Shree Pandya, James Poysky, Frederic Shapiro, Jean Tomezsko, Carolyn Constantin, for the DMD Care Considerations Working Group. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurology (in press).
• Jones, H. N., Muller, C. W., Lin, A., Banguraia, S. G., Case, L. E., Li, J. S., O’Grady, G., Heller, J. H., & Kishnani, P. S. Oropharyngeal dysphagia in infants and children with infantile Pompe disease. Dysphagia 2009. Sep 10. [Epub ahead of print]
• Case, LE, Koeberl, DD, Young, SP, Bali, D, Dearmey, SM, Mackey, J, Kishnani, PS. Improvement with ongoing Enzyme Replacement Therapy in advanced late-onset Pompe disease: A case study. Molecular Genetics and Metabolism 2008 Dec; 95 (4) 233–235.
• Kishnani PS, Berger K, Carter GT, Case LE. Late-Onset Pompe Disease: Presentation, Diagnosis, and Management. Rochester, MN: American Association of Neuromuscular & Electrodiagnostic Medicine; 2008.
• Luciano Merlini, MD; Priya Kishnani, MD; Barry Byrne, MD, PhD; Wolfgang Müller-Felber, MD; Laura Case, PT, DPT; and Ans van der Ploeg, MD. The Pompe Registry: Centralized Data Collection to Track the Natural Course of Pompe Disease. Presented at Steps Forward in Pompe Disease 2nd European Symposium in Nice, France, on November 9–10, 2007. Clinical Therapeutics/Volume 30, Supplement A, 2008.
• Case, LE, Hanna, R, Frush, DP, Krishnamurthy, V, DeArmey, S, Mackey, J, Boney, A, Morgan, C, Dorzo, D, Bouchard, S, Weber, TJ, Chen, YT, and Kishnani, PS. Fractures in children with Pompe disease: a potential long-term complication. Pediatric Radiology. 2007 May; 37(5):437-445
• Case, LE and Kishnani, PS: Physical therapy management of Pompe disease. Genetics in Medicine. 2006 May;8(5):318-27.
• Kishnani, PS, Steiner, RD, Bali, D, Berger, K, Byrne, BJ, Case, LE, Crowley, JF, Downs, S, Howell, RR, Kravitz, RM, Mackey, J, Marsden, D, Martins, AM, Millington, DS, Nicolino, M, O’Grady, G, Patterson, MC, Rapoport, DM, Slonim, A, Spencer, CT, Tifft, CJ, Watson, MS. ACMG Work Group on Management of Pompe Disease: Pompe disease diagnosis and management guideline. Genetics in Medicine. 2006 May;8(5):267-288.
• Thorpe DE , Reilly, MA, Case LE. The Effects of an Aquatic Resistive Exercise Program on Leg Strength, Balance, Energy Expenditure, Functional Mobility and Self-Perception in Children and Young Adults with Cerebral Palsy. Aquatic Physical Therapy, 2005; 13(2):21-34.
• Schlough, K, Nawoczenski, D, Case, LE, Nolan, K, Wigglesworth, JK. The Effects of Aerobic Exercise on Endurance, Strength, Function and Self-Perception in Adolescents with Spastic Cerebral Palsy: A Report of Three Case Studies. Pediatric Physical Therapy – Winter 2005, Vol 17, Issue 4, pp 234-250.
• Amalfitano, A., Bengur, AB, Morse, R, Majure, J. M., Case, LE, Veerling, DL, Mackey, J, Kishnani, P, Smith, W, McVie-Wylie, A, Sullivan, JA, Hoganson, GE, Phillips, JA, Schaeffer, GB, Charrow, J, Ware, RE, Bossen, EH, and Chen, YT. Recombinant human acid a-glucosidase enzyme therapy for infantile glycogen storage disease type II: Results of a phase I/II clinical trial. Genetics in Medicine. March/April 2001 Vol 3. No 2, pp 132-138.
   
   

  Awards and Honors

  Duke Presidential Award for Meritorious Service - 2002
  Awarded by Nannerl Keohane, PhD, President of Duke University
   
  Springfield College Physical Therapy Humanics Award - 1998
  Awarded by Springfield College – Department of Physical Therapy
   
  Outstanding Thesis Award - April 1993
  Awarded by University of North Carolina at Chapel Hill, Division of  Physical Therapy Thesis: “The Effect of Inhibitive Orthoses on Muscle Extensibility and Gait in a Child
  with Central Nervous System Dysfunction".
   
   

  FReD Publications